Analysis of the current trend in the prescription of anti-hypertensive drugs among pregnant females in a tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 4
Abstract
Background Hypertensive disorders are the leading cause of maternal and perinatal mortality and morbidity in India and worldwide, as it is among the most common of all medical complications in pregnancy. Material & Methods A single centric, observational, cross-sectional, non-randomized study conducted in the department of pharmacology in collaboration with Antenatal care (ANC) Outpatient department of Obstetrics & Gynecology. Results Among the 116 hypertensive patients, 108 patients participated in the study. Age distribution showed majority of the participants, 101 (93.51%) were in the reproductive age group i.e. 20-35 years. Trimester wise distribution of the participants showed more than half of the participants, 57 (52.77%) were in third trimester of their term. 62 (57.40%) participants were diagnosed as mild hypertensive and 46 (42.59%) as severe. Gestational hypertension was the most common of all the hypertensive disorder among the study participant. Majority of the patients, 73(67.59%), were preferred for monotherapy. Beta blocker was the preferred class as a monotherapy among the pregnant females followed by centrally acting anti-hypertensive drugs. Labetolol was the preferred antihypertensive followed by centrally acting Methyl dopa. Combination of two antihypertensive drugs was given to 12 participants and combination of anti hypertensive along with anticonvulsants was preferred in 23 participants. Combination of two drugs was used in 19 (17.59%) participants and combination of three drugs was used in 16 (14.81%) participants in the treatment of hypertension. Conclusion: Hypertension is one of the most common problems encountered in pregnancy. Monotherapy was preferred as a treatment of choice and future study should include detailed outcomes of risk and benefit for both the mother and baby.
Authors and Affiliations
Sagar B Bhagat
Keywords
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