ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CURCUMIN IN TABLET DOSAGE FORM BY RP-HPLC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
A rapid, sensitive and specific RP-HPLC method involving UV detection was developed and validated for determination and quantification of curcumin in tablet dosage form. Chromatography was carried out on a pre-packed Lichrocart Lichrosphere 250*4.0mm, 5um using filtered and degassed mixture of Sodium acetate Buffer: Acetonitrile as mobile phase at a flow rate of 1.0ml/min with gradient elution method and effluent was monitored at 250nm. The method was validated in terms of linearity, precision, accuracy, and specificity, robustness and solution stability. The method does require only 6 minutes as run time for analysis which prove the adoptability of the method for the routine analysis of the drug.
Authors and Affiliations
MV Kumudhavalli , C Saravanan , mozhi M Thamizh , B Jayakar
Keywords
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