Analytical Method Development and Validation of Tramadol Hydrochloride by Pharmaceutical Dosage Form by Ultraviolet Spectroscopy

Journal Title: Open Access Journal of Pharmaceutical Research - Year 2021, Vol 5, Issue 3

Abstract

Tramadol could be a painkiller just like an opioid. It acts within the central system (CNS) to alleviate pain. Tramadol is employed to treat moderate to severe pain in adults widely used for clinical purposes. During this respect, we aimed to develop an easy and economic UV spectrophotometric method for estimation of Tramadol Hydrochloride in bulk, injection, and tablet dosage form and validate as per ICH guidelines. Analytical research and development may be a process that assures quality attributes and internal control of the products. Tramadol shows the most absorbance at wavelength 270nm. Tramadol showed the linearity range 20-160µg per ml for this procedure with correlation (R2) was 0.9998. The current methods were found to be simple, linear, precise, accurate, and sensitive and may be used for routine internal control analysis for the estimation of Tramadol Hydrochloride bulk and tablet dosage form.

Authors and Affiliations

Nidhi S and Chaudhary M*

Keywords

Related Articles

The Influence of Cholinergic System on Rheumatoid Arthritis

Rheumatoid arthritis is one of the most prevalent immune-mediated arthritis and is categorized as a chronic, inflammatory and autoimmune disease, which mainly affects the cartilage, synovial joint, and bone, the causes o...

β-Carbonic Anhydrase as a Target for Eradication of Mycobacterium tuberculosis

Infectious diseases are among the most danger, and deadly afflictions that human societies suffering from there. One of the common re-emerged infectious diseases is tuberculosis (TB). The causative pathogen for this dise...

A Review on Self Emulsifying Nanoemulsion

Current article is focused on recent advances in the formulation and characterization of Self Emulsifying Nanoemulsions in Drug Delivery. Self-Emulsifying Drug Delivery Systems (SEDDS) are the isotropic mixtures of oil,...

Immunomodulatory Аspects and Mechanisms of Аction of βGlucans

β-glucans are found in bacterial and fungal cell walls and have been implicated in the initiation of anti-microbial immune response. β-glucansact on Dectin-1, complement receptor (CR3) and TLR-2/6 immune receptors. They...

Analgesic and Anti-inflammatory Properties of Argyreia Pilosa Wight & Arn

Background: Pain and inflammation are usually related to the pathophysiology of several medical conditions. The majority of antinociceptive and anti-inflammatory medications accessible within the merchandise found an out...

Download PDF file
  • EP ID EP748584
  • DOI 10.23880/oajpr-16000248
  • Views 19
  • Downloads 0

How To Cite

Nidhi S and Chaudhary M* (2021). Analytical Method Development and Validation of Tramadol Hydrochloride by Pharmaceutical Dosage Form by Ultraviolet Spectroscopy. Open Access Journal of Pharmaceutical Research, 5(3), -. https://europub.co.uk/articles/-A-748584