CDP-Choline Effect on Arthritis Model in Rat
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2019, Vol 3, Issue 1
Abstract
CDP-choline is a naturally occurring endogenous nucleotide, which after administration rapidly metabolizes to choline (which is a natural α7nAChR selective Agonist) and cytidine/uridine. In the body, Choline promotes several biological functions such as acting as a precursor of neurotransmitter Acetylcholine. As a result of choline availability, Ach synthesis will also increase. It is well known that nervous system under the cholinergic anti-inflammatory pathway concept has an important role in this inflammatory response mainly through α7 sub-unit of nicotinic acetylcholine receptor which is expressed by different types of immune cells, including macrophages. This pathway conducts its role mainly through stimulation of vagus nerve results in the production of Ach which is an α7nAChR Agonist. Therefore, in the light of above studies we can hypothesize that exogenously administration of CDP-Choline results in enhancement of Choline and subsequently Ach level in plasma that could antagonize α7nAChR present on various immune cells, such as macrophages and FLS; which may exert analgesic effect via decreasing pro-inflammatory cytokines production and decreasement of inflammation in arthritis pain model in rat.
Authors and Affiliations
Mehranfard D1* and Hamurtekin E2
Keywords
Related Articles
- EP ID EP746088
- DOI 10.23880/oajpr-16000174
- Views 25
- Downloads 0
Antihyperlipidemic and Antibacterial Activities of Baccaurea Courtallensis Leaves
The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat d...
Evaluation of Some Clinical Chemistry Parameters of Wistar Rats Induced with Staphylococcus aureus from Clinically Diagnosed Pneumonia Patients
The effect and extent of changes in some clinical chemistry parameters associated with pneumonia caused by Staphylococcus aureus were investigated in serum samples of Wistar rats. A total of 1500 samples were collected...
Study on the Prevalence of Hyperuricemia and Ethnobotanicals Associated with Gouty Arthritis in Rawalakot, Azad Kashmir
Hyperuricemia prevalence is an exclusive condition in the global populace as it seems to have increased day by day for a long time now. Recent studies recommend that hyperuricemia is an issue and is considered an indepe...
Occurrence of Microbial Resistence in Blood Cultures in a Teaching Hospital before and after the Restrictive Measure for the Commercialization of Antimicrobials in Brazil
Bacterial resistance to antimicrobial drugs (ATM) has become a global public health problem. The collegiate board of the National Health Surveillance Agency (ANVISA) through RDC 44, published on October 26, 2010, determi...
CDP-Choline Effect on Arthritis Model in Rat
CDP-choline is a naturally occurring endogenous nucleotide, which after administration rapidly metabolizes to choline (which is a natural α7nAChR selective Agonist) and cytidine/uridine. In the body, Choline promotes sev...