Androgenic And Antioxidant Activity Of Stelleria Media On Rat Following Sub-Chronic Exposure To Dichlorvos
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
This study aimed at investigating the possible use of Stelleria media as an antioxidant to ameliorate vital organ damage and spermatogenesis impairment induced by Dichlorvos following sub-chronic exposure of Sprague-Dawley rats at 25mg/kg/bw/day. The result revealed 10.73% loss in bodyweight, 20.16% loss in liver weight, 32.21% of testes weight, 29.91% epididymal weight indicative of systemic toxicity, damage to liver hepatocytes and reproductive organs respectively. Aspartate Transaminase and Alkaline Phosphatase were significantly (p˂ 0.05) elevated during the treatment period above control coupled with 14.53% Glucose reduction. Also elevated (p<0.05) were serum Urea, Creatinine, Total protein and Albumin. Histopathological liver micrographs of animals exposed to DDVP only revealed occurrence of binucleated hepatocytes, vacuolation, regeneration and proliferative activity associated with micronuclei. Testes of rats exposed to Dichorvos only showed inhibition of meiotic division, cellular degeneration, interstitial space devoid of Leydig cells, adluminal and luminal space showing loss of spermatogonia, sparsely populated with spermatocytes, maturing spermatozoa respectively and an empty lumen. It is concluded that Dichorvos is a systemic toxin, hepatotoxic, adversely affects the kidney and impairs spermatogenesis. With the widespread and unregulated use of this chemical in the developing countries caution in its use as an insecticide is hereby recommended.
Authors and Affiliations
Mercy Iboroma, Eme Efioanwan Orlu, Nwabueze Ebere, Adetutu Olubunmi Obulor
Keywords
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