Anti diabetic activity of the stem bark extract and fractions of Faidherbia albida Del. (Mimosaceae) in murine model.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Background: In our continued search for potent anti-diabetic compound(s) from plants and natural sources, we tested crude extract and fractions of the stem bark of Faidherbia albida - a plant traditional used in the management of diabetes mellitus in Northern Nigeria, on alloxan induced diabetic rats to obtain the most active fraction. Space and Duration of Study: The study was conducted between November 2016-March 2017 using laboratories of Departments of Pharmaceutical Chemistry and Department of Pharmacology of Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State, Nigeria. Methodology: Twenty five rats weighing between 150-200g were made diabetic with alloxan injected peritonialy. They were divided into five groups of five rats each. A sixth group of five normal fats were used for the study. They were treated with F.albida crude extract and fractions as follows; Group 1-crude extract 200mg/kg, Group 2- ethylacetate fraction 50mg/kg, Group 3- Butanol fraction 50mg/kg, Group 4- Glibenclamide 5mg/ kg, Group 5- untreated diabetic rats, Group 6- Normal rats. Treatment continued for 28 days with blood glucose and weight check weekly. Animals were sacrificed and blood samples collected for biochemical parameters. Results: The blood glucose level of the group treated with ethylacetate was lowered to 142mg/dl which compares favourably with the group treated with glibenclamide (112mg/dl) as opposed to the diabetic untreated group (380mg/dl) at the end of four weeks of treatment. Ethylacetate fraction treated rats showed the least percentage weight loss while there is a significant weight loss (= 0.05) in the diabetic rats Conclusion: Ethylacetate fraction of F.albida showed remarkable effect on blood glucose level and reduced the weight loss in diabetic rats and thus more promising to be further evaluated for bioactive substances.
Authors and Affiliations
A. J. Kashimawo1, J. A. Kolawole, J. O. Kemelayefa
Keywords
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