Anti-hyperlipidemic Activity of Thieno – [2, 3-d] - Pyrimidin-4- (3H)-ones
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 4
Abstract
Aim: The present study was aimed to evaluate some newly synthesized thieno – [2, 3-d] - pyrimidin-4- (3H)-ones namely SR-C1 to SR-C12 for their anti-hyperlipidemic activity. Materials and Methods: Anti-hyperlipidemic activity was evaluated using Triton 1339-induced hyperlipedemia in rats as an experimental model. Plasma triglycerides, total cholesterol, HDL-C, LDLC, atherogenic index (AI) and LDL-C/HDL-C ratio were determined to assess the anti-hyperlipidemic activity. Results: SR-C1,SR-C4, SR-C5, SR-C6, SR-C7, SR-C11 and SR-C12 have shown significant antihyperlipidemic activity by decreasing the total cholesterol and triglyceride, LDL-cholesterol, atherogenic index and LDL/HDL ratio (p < 0.001) and by increasing the HDL-Cholesterol (p < 0.001). Conclusion: The findings of the present study clearly demonstrates that methyl, methoxy, chloro, dimethylamino, dimethoxy and trimethoxy functional groups possess cholesterol-suppressive capacities and has an ability to attenuate the accelerated development of atherosclerosis in hypercholesterolemic models. However, hydroxyl and nitro derivatives did not show any hypolipidemic activity.
Authors and Affiliations
Rangappa Srinath| Department of Pharmacology, PES College of Pharmacy, 50 Feet Road, Hanumanthanagar Bangalore, Bangaluru-560050, Karnataka, India, Marikunte Venkataranganna| Connexios Life Sciences Pvt Ltd, Bangalore-560078, Karnataka, India, Janardhan Saravanan| Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-560050, Karnataka, India
Analysis of Macedonian Medical Scientific Papers in the Scopus Database
Aim: The aim of this study was to analyze medical scientific papers in the Republic of Macedonia indexed in the Scopus database. Material and Methods: A search of the Scopus database was performed on February 23, 2013...
Effects of Rosiglitazone on Metabolic Parameters and Adiponectin Levels in Fructose-Fed Rats
Aim. To investigate the effect of the peroxisome proliferators-activator receptor gamma agonist, rosiglitazone, on metabolic parameters and adiponectin levels in an animal model of the metabolic syndrome. Material and...
Brucellosis Control and Eradication in the South Eastern European Countries: Current Status and Perspective Strategies
Aim. To present main outputs of the International Scientific Conference on Brucellosis in South Eastern Europe (SEE) and Mediterranean Region, held in Struga, Republic of Macedonia, Nov. 12-14, 2009, and to summarize t...
Accuracy of High-Resolution Ultrasound for Evaluating Soft Tissue Tumours of the Hand and Wrist
Objectives: High resolution ultrasound (HRUS) is increasingly popular in the assessment of soft tissue tumours. This retrospective study evaluates the reliability of HRUS in diagnosing soft tissue tumours of the hand a...
Presence of Chlamydia Trachomatis in the Women’s Urethra During a Concomitant Generic Infection of Cervix Uteri
The objective of our research was to determine the presence of Chlamydia trachomatis in the women’s urethra in patients with an infection of cervix but without symptoms for a urinary infection. The study included 74...