ANTI-LIPID PEROXIDATIVE ACTIVITY OF COLOCASIA ESCULENTA LEAF JUICE AGAINST CCL4 AND ACETAMINOPHEN MEDIATED CELL DAMAGE
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 3
Abstract
The effect of free radicals on the cell metabolism is well established. Plants are rich natural sources of antioxidants, which are most effective agents to prevent free radical associated adverse cellular interactions. The purpose of this investigation was to find out the free radical scavenging efficacy associated with Colocasia esculenta whole leaf juice. The free radicals were generated using the two well known hepatotoxins CCl4 and acetaminophen. The effect of free radicals was studied on liver cells in vitro by using rat liver slice model. The liver slices were incubated in presence of cytotoxic concentrations of CCl4 and acetaminophen. Co-incubation of liver slices with the hepatotoxins and Colocasia esculenta leaf juice was conducted to assess the potency of natural components of Colocasia esculenta leaf juice in scavenging the free radicals formed due to the metabolism of CCl4 and acetaminophen. The evaluation was carried using the Thio-Barbituric Acid Reactive Substances and the total glutathione levels in the liver tissue. After the statistical treatment results revealed that the Colocasia esculenta whole leaf juice prevented the elicit of lipid peroxidative reactions caused due to the presence of free radicals generated by the hepatotoxins. Simultaneously marked elevations and prevention of depletion of total tissue glutathione were observed in presence of Colocasia esculenta whole leaf juice. From the results it is concluded that the Colocasia esculenta whole leaf juice contains free radical scavenging efficacy.
Authors and Affiliations
Bhagyashree R Patil , Faculty of Medicine, Jazan University, Jazan, Saudi Arabia
Keywords
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