ANTI-OBESITY PROPERTY OF HEXANE EXTRACT FROM THE LEAVES OF GYMNEMA SYLVESTRE IN HIGH FED CAFETERIA DIET INDUCED OBESITY RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
The hexane extract of leaves of Gymnema sylvestre was evaluated for its anti-obesity activity in the simplified high fed cafeteria diet induced obesity in Sprague dawley rats. Group-I (normal control) were fed on only basal diet without any treatment, Group-II (obesity control) were induced obesity and only on basal diet without any treatment, Group-III and Group IV were induced obesity and treated with hexane fraction of Gymnema sylvestre (150 mg/kg and 250 mg/kg body weight) respectively. Group V were induced obesity and treated with Atorvastatin as a standard drug. A significant (P>0.001) reduce in increased body weight, temperature due to obesity was observed after 45th day of treatment as compared to the normal and standard group. The extract also improved the cholesterol, triglyceride, LDL and HDL level. Blood samples were collected from retro-orbital plexus. Observed data was found statistically significant in reduction of extract-treated obesity rats. The effect of the extract was comparable to that of standard drug Atorvastatin (50mg/kg body weight).
Authors and Affiliations
Manish Kaushik , Aditi Kaushik , Renu Arya , Gajraj Singh , Poonam Malik
Keywords
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