Antianxiety and antioxidant profile of blue and white variety of Clitoria ternatea L
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
Clitoria ternatea L. (Butterfly pea; Papilionaceae) has been traditionally used in the treatment of mental disorders. But the plant has not been systematically investigated to validate its traditional claims. Thus, it was planned to compare blue and white variety of C. ternatea for antianxiety and antioxidant activities to validate traditional claims. The antianxiety activity was evaluated using elevated plus maze whereas antioxidant activity was evaluated using DPPH assay. Properly identified roots of both the varieties were separately extracted with methanol using maceration method. The methanol extract of roots of both the varieties (50, 100 or 200 mg/kg, p.o.) was subjected to antianxiety activity. The efficacy of both the varieties was statistically compared with the standard antianxiety drug, diazepam (2 mg/kg, p.o.). The root of blue and white variety showed best antianxiety activity at dose 100 mg/kg and animals spent 19.4 and 16.98 sec in open arms, respectively, in comparison to control animals (3.66 sec spent in open arms). Maximum in vitro antioxidant activity was observed in blue variety root with IC50 of 193.07 µg/ml, very closely followed by white variety root (IC50 = 220.66 µg/ml). The present studies have validated traditional claims of C. ternatea for its antianxiety activity. Finally, it can be concluded that the both the varieties of C. ternatea possess close biological profile with blue variety being more potent antianxiety and antioxidant activities.
Authors and Affiliations
Deepak Kumar, Mahaveer Dhobi
Keywords
Related Articles
- EP ID EP33387
- DOI -
- Views 299
- Downloads 0
A Study on the Antihypertensive Activity of MuktaVati (Ayurvedic Preparation) In Deoxycorticosterone acetate (DOCA) salt Induced Hypertension in Rats
Mukta vati, an ayurvedic formulation is being routinely used to treat cardiovascular ailments like hypertension. However, so far its antihypertensive effect has not been validated in any animal model of hypertension. T...
INVESTIGATION OF IN-VITRO ANTI-OXIDANT, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF AERIAL PARTS OF SECURINEGA LEUCOPYRUS (WILLD.) MUELL
Securinega leucopyrus (willd.) Muell. (Euphorbiaceae) is a thorny, large shrub or small tree. In Ayurveda it has a lot of potential medicinal uses. The decoction of leaves are used to dress the cancerous wounds. The ju...
Pharmacological intervention of the fruit of plant Ananas comosus acting as hepatoprotective activity in animal models
In the initial step of the project work various extracts of ripe fruits have been prepared by using successive extraction procedure and thus obtained extracts were subjected to preliminary phytochemical screening. Prel...
Conservative management of allergic respiratory illness in the light of Ayurveda & Plant Biotechnology: A literary review
The term Allergy refers to expression of an ‘altered state of reactivity’ to common environmental antigens. Allergic diseases have a familial predisposition and common target organs are lungs, nose and skin. Common all...
Role of reverse pharmacognosy in finding lead molecules from nature
Alternative systems of medicine viz. Ayurveda, Siddha and traditional system of Medicine have become more popular in recent years and have proven their significance in medical sciences [1]. Combining the strength of kn...