Antianxiety and antioxidant profile of blue and white variety of Clitoria ternatea L
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
Clitoria ternatea L. (Butterfly pea; Papilionaceae) has been traditionally used in the treatment of mental disorders. But the plant has not been systematically investigated to validate its traditional claims. Thus, it was planned to compare blue and white variety of C. ternatea for antianxiety and antioxidant activities to validate traditional claims. The antianxiety activity was evaluated using elevated plus maze whereas antioxidant activity was evaluated using DPPH assay. Properly identified roots of both the varieties were separately extracted with methanol using maceration method. The methanol extract of roots of both the varieties (50, 100 or 200 mg/kg, p.o.) was subjected to antianxiety activity. The efficacy of both the varieties was statistically compared with the standard antianxiety drug, diazepam (2 mg/kg, p.o.). The root of blue and white variety showed best antianxiety activity at dose 100 mg/kg and animals spent 19.4 and 16.98 sec in open arms, respectively, in comparison to control animals (3.66 sec spent in open arms). Maximum in vitro antioxidant activity was observed in blue variety root with IC50 of 193.07 µg/ml, very closely followed by white variety root (IC50 = 220.66 µg/ml). The present studies have validated traditional claims of C. ternatea for its antianxiety activity. Finally, it can be concluded that the both the varieties of C. ternatea possess close biological profile with blue variety being more potent antianxiety and antioxidant activities.
Authors and Affiliations
Deepak Kumar, Mahaveer Dhobi
Keywords
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