Pharmacological intervention of the fruit of plant Ananas comosus acting as hepatoprotective activity in animal models
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
In the initial step of the project work various extracts of ripe fruits have been prepared by using successive extraction procedure and thus obtained extracts were subjected to preliminary phytochemical screening. Preliminary phytochemical tests have indicated the presence of tannins, triterpene and flavonoids in aqueous and ethanolic extracts. Similarly steroids are also present in petroleum ether and chloroform extracts of ripe fruits of Ananas comosus. Rats treated with alcohol developed a significant hepatic damage observed as elevated serum levels of hepatospecific enzymes like SGPT, SGOT and ALP when compared to normal control. Treatment with Silymarin had showed good protection against alcohol induced toxicity to liver. Groups treated with ethanolic and aqueous extracts of fruits of Ananas comosus showed significant effects.
Authors and Affiliations
Debashis Mallik, Chiranjib Bhattacharjee, T. Shivraj Gouda
Keywords
Related Articles
- EP ID EP33213
- DOI -
- Views 306
- Downloads 0
STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF CEFTAZIDIME PENTAHYDRATE AND TAZOBACTAM SODIUM IN BULK AND DOSAGE FORMS
A simple rapid, accurate, precise and reproducible validated reverse phase HPLC method was developed for the determination ofCeftazidimepentahydrate and Tazobactam sodium in bulk and pharmaceutical dosage forms. The qu...
Review on effect of combination drug therapy on diabetes mellitus and its management
Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin produced by the pancreas lowers blood glucose. Absence or insufficient production of insulin causes diabet...
A Study on the Antihypertensive Activity of MuktaVati (Ayurvedic Preparation) In Deoxycorticosterone acetate (DOCA) salt Induced Hypertension in Rats
Mukta vati, an ayurvedic formulation is being routinely used to treat cardiovascular ailments like hypertension. However, so far its antihypertensive effect has not been validated in any animal model of hypertension. T...
Emulsifiers as reducer of fat in foodstuffs
Emulsion includes a non-homogenous system composed of two non-immiscible liquid where one distributed in form of droplets with 0.1µm. Emulsifiers create a thin layer on the surfaces which increases dough viscosity thro...
Formulation and in-vitro evaluation of Aceclofenac loaded topical Emulgel
Gels are a relatively newer class of dosage form created by entrapment of large amounts of aqueous or hydro alcoholic liquid in a network of colloidal solid particles. Gel formulations generally provide faster drug rele...