Antianxiety effect of aqueous extract of fruits of Emblica officinalis(EO) on acute and chronic administration in rats.
Journal Title: Journal of Pharmacy Research - Year 2010, Vol 3, Issue 2
Abstract
The present study was undertaken to evaluate the anti-anxiety activity of aqueous extract of fruits of Emblica officinalis (EO) on acute and chronic administration in rats. Male Wistar albino rats weighing 150-180gms were divided into five groups (n=6) for acute and chronic study separately. Diazepam (1.0mg/kg) and EO (0.8, 2.0 & 4.0 mg/kg) were suspended in 1% gum acacia and administered orally. In acute study vehicle/drugs were given 60 minutes before, while in chronic study they were given once daily for 10 days and the last dose was given 60 min prior to exposure to the experimental paradigms viz., elevated plus maze and bright and dark arena. EO significantly increased the number of entries into, time spent and rears in the open arms. Also, it increased the percentile ratio of open arm to total arm entries in elevated plus maze paradigm both on acute and chronic administration. In bright and dark arena paradigm the EO both on acute and chronic administration it significantly increases the number of entries, time spent and rears in the bright chamber, also it reduced the duration of immobility. These behavioural changes were comparable to that produced by the standard anxiolytic drug diazepam. The behavioural disinhibition produced by EO suggestive of its anxiolytic like activity.
Authors and Affiliations
Pemminati Sudhakar, Gopalakrishna HN, Swati B, Shreyasi C, Pai MRSM, Vinod Nair
Keywords
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