Antibiotic resistance pattern of enterococcal isolates from patients with urinary tract infection
Journal Title: International Journal of Biomedical Research - Year 2018, Vol 8, Issue 6
Abstract
Background: Enterococci are the most common cause of healthcare associated urinary tract infections. The frequency of isolation of Enterococci from urinary tract of hospitalized patients has risen. Enterococcus is considered as an important nosocomial pathogen because of its intrinsic as well as acquired resistance to antibiotics. The purpose of this study is to determine the emergence of Enterococci as uropathogens and their antimicrobial susceptibility pattern. Materials and methods: This cross sectional study was conducted at the Department of Microbiology, A.C.S Medical College and Hospital. A total of 175 Enterococcus spp were isolated from patients with urinary tract infection. Identification and speciation of the Enterococcal isolates were done using conventional method. The antibiotic susceptibility testing of the Enterococcal isolates was performed by modified Kirby-Bauer disk diffusion method as per Clinical Laboratory Standard Institute (CLSI) guidelines. Results: A total of 175 urine specimens yielding the growth of Enterococci were studied. Enterococcus faecalis (77.7%) was the predominant species isolated followed by E. faecium (20%) and E. durans (2.3%).The sensitivity pattern of the isolates showed an increased resistance to antibiotics like erythromycin (66.3%), ciprofloxacin (56%) and penicillin (49.7%). The HLAR (High Level Aminoglycoside Resistance) to gentamycin was observed in 37.2%, however the susceptibility rate of nitrofurantoin was 86.9%, amoxicillin - clavulanic acid was 81.1% and ampicillin (21.7%). Among the isolated Enterococci, 5.7% were vancomycin resistant. All the Enterococci were found to be sensitive to linezolid. Conclusion: Enterococci have emerged from being harmless commensals to versatile lethal pathogens. In our study, E.faecalis was the most frequently isolated species followed E.faecium. Linezolid, vancomycin, nitrofurantoin and amoxicillin-clavulanic acid were found to be the most effective antimicrobials against Enterococci isolated from patients with UTI. However vancomycin or linezolid therapy should be restricted for use in patients infected with MDR strains only. Although the frequency of isolation of VRE is not very high in our setting, this may be the beginning. Tracking of antimicrobial susceptibility due to increasing resistance rate is very important in treatment of Enterococcal infections.
Authors and Affiliations
Kalpana Devi Venkatesan, Senthil Chander, Ananthi B, Sopia Abigail, Kalavathy Victor
Keywords
Related Articles
- EP ID EP452420
- DOI 10.7439/ijbr.v8i6.4182
- Views 94
- Downloads 0
Pan genotypic response to combination treatment with Sofosbuvir and Daclatasvir in chronic Hepatitis C patients
Background and aims: Hepatitis C is a major cause of liver related morbidity and mortality. Prevalence of HCV infection in India has been variously estimated as 0.9 to 1.9%. With the advent of DAAs, the treatment has bee...
Interaction of aldose reductase and superoxide dismutase activity in liver; influence of vasopressin hormone and its modulators
The Liver is an important organ of the body for carbohydrate metabolism which include ureogenesis, glycogenolysis, gluconeogenesis. The pituitary hormone vasopressin mediates its actions on the carbohydrate metabolism th...
Issues and Controversies Concerned to the Practical Ethical Discourse of Biotechnology
Over the past decade the biotechnological world has changed the way we lived and emerged from the research laboratory to the market and has reached to the consuming public and government. The biotechnological advancement...
Sarcomatous lesions of Mediastinum - An unchartered territory: A tale of two case reports
Various primary and metastatic malignant lesions can occur in the mediastinumandmay cause diagnostic dilemmas in achieving definitive diagnosis. Synovial sarcoma is a malignant neoplasm predominantly affecting soft tissu...
Financing universal coverage in Kenya A case study
Introduction: One of the challenges to maintain an agenda for universal coverage and equitable health system is to develop effective structuring and management of health financing. Global experiences with different syste...