Sarcomatous lesions of Mediastinum - An unchartered territory: A tale of two case reports
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 9
Abstract
Various primary and metastatic malignant lesions can occur in the mediastinumandmay cause diagnostic dilemmas in achieving definitive diagnosis. Synovial sarcoma is a malignant neoplasm predominantly affecting soft tissues of the extremities of adolescents and young adults. Its occurrence as a primary neoplasm in mediastinum is rare. Ewing's sarcomas are also rare high grade malignant neoplasms that predominantly affect children and young adults and involve the major long bones, pelvis, and ribs. Primary mediastinal Ewing's sarcoma is extremely rare. We, hereby, presenttwo unusual casesof sarcoma in mediastinum. First case was a 62 year old male patient presented withchest pain and cough. Microscopic examinations of the resected mediastinal tumor showed areas of epithelial differentiation with well-formed glandular spaces intimately admixed with monotonous population of plump spindle-shaped cells confirming the diagnosis of synovial sarcoma. Another case of 23 years old male patient presented with chest pain and cough. Microscopic examinations of the mediastinal mass revealed presence of a tumor tissue composed of sheets and nests of small round cells with hyperchromatic nuclei and scanty cytoplasm. Histopathological diagnosis of Ewings sarcoma was made. In conclusion, it can be said that mediastinum could be rarest of the rare locations for primary sarcomas our search for literature also revealed very few cases across the globe which imparts further credence to the true rarity of the neoplasm. Early management by the oncologist may be hindered further owing to diverse differential diagnosis unless surgical pathologists undertake a cautious pragmatic approach.
Authors and Affiliations
Soham Chakraborty, Dr Sanghamitra Mukherjee, Manisha Mahata, Rajarshi Gayen, Nabanita Chakraborty, Dr. Tushar Kanti Das
Keywords
Related Articles
- EP ID EP391895
- DOI 10.7439/ijbr.v6i9.2538
- Views 107
- Downloads 0
Atypical young presentation of lipoma arborescens of knee with USG and MRI correlation
Lipoma arborescens of the knee joint is a rare entity and only a few cases have been documented in literature. It is described as an idiopathic rare joint disease in which benign fatty deposits replace and distend the sy...
Lingual Schwannoma A common tumor in uncommon location
Schwannoma (neurilemmoma) is a solitary, benign, truly encapsulated tumor originating from proliferating Schwann cells of nerve sheath. Though the overall incidence of Schwannoma is 25-45% in head & neck region, only 1%...
Water, hygiene and sanitation practices amongst medical students in Moi University Eldoret, Kenya
Background: Hand washing with soap and water is one of the most effective and inexpensive means of preventing infections. Rates of hand washing are low worldwide even amongst health care workers who should know about its...
Clinicopathological study of cutaneous vasculitis
Introduction: Cutaneous vasculitis hasvaried clinical manifestations. It may be idiopathic or associated with a spectrum of underlying conditions. Skin is involved in both small vessel vasculitisand medium vessel vasculi...
Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets
Epitheliotropic and mucosotropic Papillomaviruses (PVs) constitute the Papillomaviridae family. There are 26 genera comprising levels of inter species genetic similarities by nucleotide sequence analysis of the L1 viral...