Antidepressant Activity Of DPP-4 Inhibitors In Albino Mice, An Experimental Study

Apply

Antidepressant Activity Of DPP-4 Inhibitors In Albino Mice, An Experimental Study

Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 4

Abstract

Objective: To evaluate the antidepressant activity of DPP-4 INHIBITOR in mice. Methods: Sixty adult Swiss albino mice weighing 25-30 grams were selected. Thirty were allocated to forced swim test and thirty to tail suspension test models. In each model there were 6 groups. The control group received vehicle (10 ml/kg, p.o) as standard, Imipramine (10mg/kg p.o) and the other groups received sitagliptin linaglitin, saxagliptin, vildagliptin respectively 1 hour prior to the acute study. In chronic study, the drugs were given orally once a day for 10 days and the last dose was given 1 hour before the experiment. Duration of immobility was noted in forced swim test and tail suspension test. Statistical analysis was performed using Mean +/- SEM. ANOVA followed by Dunnett’s test. P< 0.05 was considered statically significant Results:DPP-4 inhibitors produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the standard. The antidepressant effect was higher with sitagliptin and linagliptin when compared to saxagliptin ,vildagliptin and control. Conclusion: DPP-4 inihibitors sitagliptin and lingaliptin has shown significant antidepressant activity greater than imipramine in mice.

Authors and Affiliations

Saritha MK, Chandrashekar K

Keywords

Comparison Of Two Root Coverage Procedures: Subcutaneous Connective Tissue Graft And Lateral Pedicle Flap: A Clinical Study

AIM:The aims of the study are to compare two graft procedures for the amount of root coverage and the cosmetic integration of the operated zone within the mouth. Material And Method:Thirty patients with Miller’s class I...

EP ID EP574223
DOI -
Views 112
Downloads 0