ANTIDIABETIC ACTIVITY OF 2-AMINO-(5-FLUORO-2-OXOINDOLIN-3-YLIDENE) BENZOXAZOLE-5-CARBOHYDRAZIDE IN RATS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 6
Abstract
The present study was designed to evaluate the antidiabetic activity of new indole derivatives i.e 2-Amino-(5-fluoro-2-oxoindolin-3-ylidene) benzoxazole-5-carbohydrazide against alloxan induced diabetic rats. Alloxan (120mg/kg) was used to induce diabetes in rats and the blood glucose levels were estimated by using commercial kit in the market. The test compound was administered to diabetic rats as single dose for one day at a dose of 50 & 100 mg/kg. The compound produced a significant reduction (p<0.01) of blood glucose levels at a dose of 50 & 100mg/kg in diabetic rats in a dose dependant manner.
Authors and Affiliations
Rama Narsimha Reddy Anreddy*| Department of Pharmacology, Vaageswari College of Pharmacy, Karimanagar-505481, Telangana State, India
Keywords
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