STUDY OF PHYTOCHEMICAL SCREENING, ANTIOXIDANT, ANTIDIARRHOEAL AND ANALGESIC ACTIVITIES OF HYDROMETHANOL EXTRACTS OF POLYALTHIA SUBEROSA (ROXB.)
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
Hydromethanol extracts of three different parts namely leaves, bark and fruits of the Polyalthia suberosa (Roxb.) was screen for it’s antioxidant, analgesic and antidiarrheal activity. Bark extracts showed the maximum reducing activity in both model and higher than the reference standard ascorbic acid. Fruits extract was also found to have strong reducing capacity but slightly lower compared to the ascorbic acid. The analgesic activity of all parts of P. suberosa at all doses, produced significant (p<0.05-0.01) inhibition of writhing reaction in a dose dependent manner. Maximum inhibition of writhing (55.15% inhibition) was produced by the bark extract at 400 mg/kg dose whereas fruits and leaves extracts at the same dose displayed a maximum of 53.09% and 38.92% inhibition of writhing response respectively and at the dose of 200 and 400 mg/kg, produced a significant (p<0.05-0.001) increase in pain threshold in tail immersion methods in a dose dependent manner after 60 and 90 min of drug administration. In castor oil-induced diarrhoea statistically significant (p<0.05) inhibition of frequency of diarrhoeal was observed with bark (69.52% inhibition) and fruits (63.81% inhibition) of the plant at 400 mg/kg dose level. Similarly in MgSO4-induced diarrhoeal model, the antidiarrhoeal actions exhibited by the hydromethanol extracts of the three parts of the plant, at 400 mg/kg dose, were found to be statistically significant (p<0.05) and was comparable to the reference drug Loperamide.The overall results were bark and fruits extracts of Polyalthia suberosa possess strong antioxidant potential along with excellent analgesic and antidiarrheal activity while leaves extract possess moderate activity.
Authors and Affiliations
Zubair Khalid Labu*| World University of Bangladesh (WUB), Munira Makshud| Advance Chemical Industry (ACI), Narayanjang, Samiul Basir| World University of Bangladesh (WUB), Jalal Uddin| World University of Bangladesh (WUB), Sukdeb Biswas| World University of Bangladesh (WUB), Nadia Sultana| World University of Bangladesh (WUB)
Keywords
Related Articles
- EP ID EP1776
- DOI -
- Views 393
- Downloads 22
SONOGRAPHIC MEASUREMENTS OF THE SPLEEN IN RELATION TO AGE; A PROSPECTIVE STUDY IN EASTERN NEPALESE ADULTS.
To establish the normal range of the splenic dimensions in East Nepalese adult population ,we used ultasonography to examine 120 subjects ( 60 males and 60 females ),15 each of age group 31-40yrs,41-50yrs,51- 60yrs,61-...
Does Rottlerin or its congeners have a potential as adjuvant to antidote therapy of spider/snake venom intoxication?
Rottlerin is a polyphenol natural product isolated from the tree Mallotusphilippensis. Rottlerin displays a complex spectrum of pharmacology. Rottlerin has been shown to be an uncoupler of mitochondrial oxidative phospho...
PREVALENCE OF OBESITY IN YOUNG ADOLESCENTS OF URBAN BHOPAL
Background: As the country’s economy is improving at exponential rate, living habits of Indian population has changed abruptly leading to rapid proliferation of fast food centers thus increase in consumption of fatty fo...
SENSITIVITY PATTERN OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM SURGICAL SITE INFECTIONS
Surgical site infections are an important cause of health care associated infections among surgical patients. Patients who develop surgical site infections have longer hospital stays, more expensive hospitalizations, and...
FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF ATORVASTATIN CALCIUM
In present work was designed to develop suitable transdermal matrix type of Atorvastatin calcium, using Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) with PEG 400, n-DB (as plasticizers) and propylene...