Antidiabetic activity of ethanolic extract of Heliotropium indicum whole plant against alloxan and streptozotocin induced diabetics in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 1
Abstract
The present research was carried out to evaluate Antidiabetic activity of Heliotropium indicum ethanolic extract in alloxan and streptozotocin induced diabetic rats Helitropium indicum whole plant was extracted using ethanol as solvent by Soxhlet apparatus. The extract was subjected to preliminary phytochemical screening. Acute oral toxicity studies were performed to determine test dose. Alloxan and streptozotocin were used for inducing diabetes in albino Wistar rats. Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides, saponins, tannins flavonoids, proteins, and amino acids. Doses up to 2000mg/kg were found to be safe after acute toxicity tests. The results suggested that EHI possess anti diabetic activity against diabetes induced by both alloxan and streptozotocin.
Authors and Affiliations
Syed Safiullah Ghori
Keywords
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