ANTIHYPERGLYCEMIC ACTIVITY STUDIES WITH METHANOLIC EXTRACT OF WHOLE PLANTS OF PIPER SYLVATICUM
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 1
Abstract
Background: Piper sylvaticum, known as pipul in Bangladesh and Mountain Long Pepper in English is considered a medicinal plant by traditional medicinal practitioners in various countries. The objective of the present study was to evaluate whether methanolic extract of the whole plant (MEPS) possess antihyperglycemic activity. Methods: Oral glucose tolerance test (OGTT) was done to evaluate antihyperglycemic efficacy. Results: In oral glucose tolerance tests, MEPS dose-dependently and significantly reduced blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, MEPS lowered blood glucose levels by 25.9, 31.4, 40.4, and 49.4%, respectively, compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide reduced blood glucose levels by 29.7% at a dose of 10 mg per kg. Conclusion: The whole plant can be an effective means for lowering blood glucose in persons with elevated blood glucose levels like people with diabetes.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
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