Antimicrobial Effect of SimaroubaGlauca( LakshmiTaru) on Opportunistic Pathogens in HIV/AIDS patients
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Severalplant extracts exhibit antimicrobial activity against microbial pathogens. This suggests that plants which manifest relatively high levels of antimicrobial action may be the source of compounds that can be used to inhibit the growth of human pathogen[4] One of the ethnomedical plants Simaroubaglauca was investigated for Gas Chromatography Mass Spectrometry ( GCMS ) analysis to determine the chemical constituents present in different extracts of its leaves. The powdered leaf was subjected to successive extraction with five organic solvents. Out of 88 compounds reported most of the compounds were found to be medicinally effective, which could be useful against opportunistic infections in patients with poor immunity. The current work focuses on the extraction and assay of antimicrobial components from the leaf of Simaroubaglauca and also to evaluate their antioxidentalpotential, which is probably a new alternative for arresting the opportunistic infections in HIV/ AIDS patients thus extend their life span. The clinical samples collected from HIV/AIDS patients were used to isolate the most commonly found opportunistic infections causing pathogens namely Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Candida albicans. Extracts from leaves of Simaroubaglauca were tested against the above mentioned organisms and they were found to be effective. In addition to all phytochemical compounds needed farther investigations for toxicological aspects leading to therapeutic uses.
Authors and Affiliations
Jancy Varghese, S . Rajamani2, Betty Daniel3
Keywords
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