ANTIMICROBIAL POTENCY SCREENING OF CLERODENDRUM INFORTUNATUM LINN.
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
Plants play a major role in all the traditional system of medicine. Plants contain the rich source of natural products like vitamins, minerals and other immune-modulators. Most of which have been used for human welfare specially to cure disease caused by pathogenic microorganisms. The present study was conducted to determine the antimicrobial activity of C. infortunatum (Verbenaceae) with two different solvents viz; ethanol and ethyl acetate against medically important pathogens such as six gram positive bacterial strains, nine gram negative bacterial strains and seven fungal strains. The in vitro screening for antimicrobial activity was carried out by using disc diffusion and micro broth dilution techniques. All the extracts showed significant inhibitory activity over the bacteria and fungus comparable to the standard drug tetracycline and fluconazole. The maximum diameter zone of inhibition was recorded to bacterial strains against B. megaterium and B. subtilis; S. typhi, S. shiga and K. pneumoniae and to fungi against A. niger, A. flavus and C. albicans. The MIC values of ethanol leaf extract were determined 64 µg/ml to B. megaterium, S. typhi and K. pneumoniae; 128 µg/ml to S. aureus, S.-β–haemolyticus and E. coli according to the serial dilution technique. Most of the extracts of root, leaf and stem of C. infortunatum are effective against both organisms; bacteria and fungi, especially leaf extract > root extract > stem extract. Thus, C. infortunatum appears to be an effective material for development of antimicrobial drugs.
Authors and Affiliations
Muhammad Waliullah, Mst Yeasmin, Alam Ashraful, Md Islam , Parvez Hassan
Keywords
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- EP ID EP120960
- DOI 10.7897/2230-8407.050211
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