Antimicrobial Property of Lemon Grass Oil against Aggregatibacter Actinomycetemcomitans.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 3
Abstract
Background: Lemon grass has been used in treatment of many diseases. Hence this study was aimed to determine antibacterial action of lemon grass oil against the Aggregatibacter Actinomycetemcomitans. Materials and methods: Lemon grass was dried and hydrodistillation was performed to obtain the oil used in the study. GCMS analysis was done to know the compounds of lemon grass which effective against Dispersin B of Aggregatibacter Actinomycetemcomitans. Molecular docking technique was done to study these compounds obtained after GCMS analysis. Finally, minimum inhibitory concentration was done to know the antibacterial activity of lemon grass oil components against Aggregatibacter Actinomycetumcommitans. Results: In the present study a total of 11 compounds were obtained after GCMS analysis but 3 compounds were selected as the compounds that were expected their presence in essential oil. The chemical compounds used for study were Citronellol, D-Limonene and Geraniol. D-limonene however exhibited good binding with a score of -6.1. Citronellol exhibited a binding score of -4.9 whereas Geraniol exhibited a binding score of -5.5 for Aggregatibacter Actinomycetemcomitans. The minimum concentration of Cymbopogon citrates (lemon grass) causing inhibition was 150μg/ml and 200 μg /ml respectively. The maximum effect was found using 200 µl and minimum effect was observed with 50µl of lemon grass oil. Conclusion: The active ingredients from lemongrass oil containing Citronellol, D-Limonene and Geraniol showed antibacterial activity against Aggregatibacter Actinomycetemcomitans with MIC of 15µl/ml. Therefore, formulations encompassing these compounds can be used to treat plaque induced periodontal disease.
Authors and Affiliations
Dr Shivaprasad Bilichodmath
Keywords
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