Antimicrobials resistance: need for a rational approach
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2015, Vol 1, Issue 1
Abstract
In current scenario world is entering into the antibiotic resistant era. Serious infections caused by bacteria are increasingly becoming resistant to the currently available antimicrobial agent. These infections are not only causing morbidity and mortality but also leads to financial burden to the individual, society and ultimately to the nation. The greater concern is spread of these infections from hospitals to the community. Microbes have developed resistance to nearly all different classes of antibiotics discovered till date. Resistance found commonly is acquired and transmitted horizontally via the conjugation of a plasmid. Recently new mechanisms of resistance have resulted in the simultaneous development of resistance to several antibiotic classes creating very dangerous multidrug-resistant (MDR) bacterial strains, some also known as ‘‘superbugs’’. Indiscriminate and inappropriate use of antimicrobial in outpatient clinics, hospitalized patient and in livestock is the most important factor for antimicrobial resistance. Recently pharmaceutical industries have slowed or terminated their anti-infective research programs due to economic reasons. This decrease in the number of new antimicrobial along with the antimicrobial resistance has triggered the post antibiotic era i.e., age when the antibiotics will be the thing of past. Now it is high time to think about formulating the strategies by the industry, academia and the government for safe and effective use of antibiotics.
Authors and Affiliations
Hitesh Mishra, Harihar Dikshit
Keywords
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