Antinephrotic potential of CATCAB-50 in CCL4 induced glomerulonephritic animal
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 3
Abstract
Objective: Present study was designed to evaluate antinephrotic potential of CATCAB-50 in CCl4 induced glomerulonephritis (GN) in Wistar rats. Methods: The poly herbal formulation CATCAB-50 has contained fresh dried root extract of six medicinal herbs i. e. Carica papaya, Angelica officinalis, Tinospora cordifolia, Cissampelos pareira, Achyranthes aspera and Boerhaavia diffusa, which was scientifically validated for the management of GN. The antinephrotic potential was evaluated in pre-treating group of rats with dose of 50mg/kg b.w. of CATCAB aqueous extract for 10 days in respect to carbon tetrachloride (CCl4 1.5ml/kg b.w.) induced GN. Result: The aqueous extract of CATCAB-50 on hematological and biochemical parameters for its pharmacological screening of all groups were measured using standard procedures. Histological studies of rat kidney of all experimental group animals were also completed for its confirmation. Results showed that intraperitoneal injection of CCl4 induced, significant (p<0.05) elevation in the hematological parameter and urine levels of total protein, uric acid, urea and creatinine. Conclusion: However, elevated biochemical parameters were significantly (p<0.05) attenuated in rats pre-treated with CATCAB-50, could be mediated by any of the phytocomponents present in it via either antioxidant and/or free radical scavenging mechanism.
Authors and Affiliations
Harikesh Maurya, Tirath Kumar
Keywords
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