Development and evaluation of buccal film of norethindrone for birth-control
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 1
Abstract
Norethindrone is the class of progesterone which is used to prevent pregnancy. The plasma levels were considerably higher in women than men, especially at low dose levels. The plasma half –life of norethindrone is about 5 hrs in both sexes with single oral doses of 5 to 20 mg. Hence the present research work includes formulation of mucoadhesive buccal film of norethindrone with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study five formulation of norethindrone were prepared as buccal film, by solvent casting technique. Sodium carboxymethylcellulose, hydroxylpropylmethy lcellulose and polyvinylpyrrolidone were used as mucoadhesive polymers. Prepared films were evaluated for their weight, thickness, surface pH, swelling index, drug content uniformity, folding endurance in vitro release and permeation studies.
Authors and Affiliations
Ujjwal Nautiyal, Shalini Sharma, Devendra Singh, Satinder Kakar, Shavina Gupta, Alok Semwal, Ramandeep Singh
Keywords
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