In-Vitro Cytotoxicity Study of Some Indigenous Medicinal Plants on Vero Cell Line
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 2
Abstract
The ethno botany and ubiquitous plants as a source of medicine has been an important component of the health care system providing a rich resource for natural drug research and development. Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads, because of unmatched availability of chemical diversity. In the present study, six commonly used plants, Amla, Baheda, Harde, Ashwagandha, Turmeric and Kali Musli are selected. The in-vitro cytotoxicity study has been done using MTT assay on the Vero cell line using cisplatin as a standard drug for toxicity. The hydroalcoholic extracts of the above drugs have been tested for their cell viability at different concentrations, ranging from 100 µg/ml to1000 µg/ml. From the performed assay, almost all the plants did not show any significant cytotoxic effect on the Vero cells, promoting their use as potential nephro-protective agents. The possible mechanism of action can further be validated by identifying the molecules from the plant extracts and subjecting them to various studies like docking studies, and their binding affinity with the targets.
Authors and Affiliations
DR. Bhatt, K. Jethva, MN. Zaveri
Keywords
Related Articles
- EP ID EP31514
- DOI -
- Views 369
- Downloads 1
Particle coating: From conventional to advanced
Powder particle coating is the most important technique in pharmaceutical industry. It has constantly being refined and modified since last four decades. There are numerous applications of coating, including drug laye...
A Study on Correlation of Anthropometric measures and HbA1c in asymptomatic young adults
Introduction: Anthropometric measures are important risk factors for development of non- insulin dependent Diabetes. Previous studies have shown that body mass index (BMI) and waist circumference as well as other anthrop...
Fast Dissolving Tablets – Future Aspects
The Fast Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970’s and combat over the use of the tablets, syrups, capsules which are the other oral drug delivery systems.Oral rou...
Primary Non-Hodgkin Lymphoma of Sigmoid Colon: A Rare Presentation
Primary lymphoma of the colon is a rare tumor of the gastrointestinal (GI) tract and comprises only 0.2-1.2% of all colonic malignancies. The most common variety of colonic lymphoma is NonHodgkin's lymphoma (NHL). The G...
A Review on current scenario of Pharmacosomes
Limited permeation into the cells and the adverse effects are the major detriments with most of the drugs used in the chronic disorders. So from the past few decades our focus is on the advanced drug delivery system whic...