In-Vitro Cytotoxicity Study of Some Indigenous Medicinal Plants on Vero Cell Line
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 2
Abstract
The ethno botany and ubiquitous plants as a source of medicine has been an important component of the health care system providing a rich resource for natural drug research and development. Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads, because of unmatched availability of chemical diversity. In the present study, six commonly used plants, Amla, Baheda, Harde, Ashwagandha, Turmeric and Kali Musli are selected. The in-vitro cytotoxicity study has been done using MTT assay on the Vero cell line using cisplatin as a standard drug for toxicity. The hydroalcoholic extracts of the above drugs have been tested for their cell viability at different concentrations, ranging from 100 µg/ml to1000 µg/ml. From the performed assay, almost all the plants did not show any significant cytotoxic effect on the Vero cells, promoting their use as potential nephro-protective agents. The possible mechanism of action can further be validated by identifying the molecules from the plant extracts and subjecting them to various studies like docking studies, and their binding affinity with the targets.
Authors and Affiliations
DR. Bhatt, K. Jethva, MN. Zaveri
Keywords
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