Antioxidant and cytotoxic potential of methanol extract of Tabernaemontana divaricata leaves
Journal Title: International Current Pharmaceutical Journal - Year 2012, Vol 1, Issue 2
Abstract
The methanolic extract obtained from the leaves of [i]Tabernaemontana divericata[/i] (Family: Apocynaceae) was evaluated for[i] in vitro[/i] antioxidant potential by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. The extract was also screened for its cytotoxic effect using brine shrimp lethality bioassay. The results revealed potent antioxidant property in all antioxidant assays compared to the reference antioxidant, ascorbic acid in a dose dependent manner. Further, the methanolic extract of [i]Tabernaemontana divericata[/i] showed significant cytotoxic effect (LC[sub]50[/sub]: 3.12µg/ml) compared with positive control, Vincristine Sulphate (LC[sub]50[/sub]: 0.331µg/ml).
Authors and Affiliations
Nowshin Rumzhum, Mostafizur Rahman, Khalequzzaman Kazal
Keywords
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- EP ID EP145535
- DOI http://dx.doi.org/10.3329/icpj.v1i2.9446
- Views 107
- Downloads 0
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