ANTIOXIDANT POTENTIAL OF PUNICALAGIN IN AN IN-VITRO SYSTEM OF PRECISION CUT GOAT LIVER SLICES SUBJECTED TO OXIDATIVE STRESS
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 10
Abstract
Oxidative stress has been implicated in various pathological diseases like neurodegenerative disorders, stroke, cancer, inflammation, atherosclerosis, etc., which upshots when the production of reactive oxygen species overwhelms the antioxidant defense mechanism. Nowadays, development of drugs with antioxidant potential gained utmost importance therapeutically to treat many pathological diseases. Plant-derived anti-oxidants were proven to be more effective than synthetic antioxidants. With this as focus, the present study investigated the antioxidant potential of punicalagin (PG) in an in-vitro system of goat liver slices imperiled to oxidative stress. Precision cut goat liver slices are used as an in-vitro model for the evaluation of anti-oxidant activity because it crafts in-vivo tissue environment and helps in curtailing the use of intact animals. In our study, hydrogen peroxide is used as an oxidant to create oxidative stress to the liver slices. Hydrogen peroxide treated liver slices showed a significant decrease in both enzymatic and non-enzymatic antioxidant levels as compared with normal liver slices. PG treated liver slices showed significant improvement in both enzymatic and non-enzymatic antioxidant levels as compared with untreated control group. From our results, it was observed that PG showed significant anti-oxidant activity in an in-vitro system of goat liver slices subjected to oxidative stress which confirms the antioxidant potential of punicalagin.
Authors and Affiliations
S. Thakur et al.
PHYTOPHARMACOGNOSTICAL INVESTIGATION OF SAMASARKARA CHURNA
Introduction: Samasarkara churna is the Ayurvedic medication preferred treatment of dyspepsia, loss of appetite and piles, formulated by mixing powder of cardamoms, long piper, black piper, flowers of Mesua ferrea, cinna...
SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES
A series of substituted acetophenones are condensed with hydrazides to the corresponding hydrazones which are subsequently cyclized by using vilsmier-Haack reaction to give new pyrazole derivatives. All the compounds 4a,...
ANTIFUNGAL ACTIVITY OF SELECTED PLANT EXTRACTS ON PERIDIOPSORA MORI CAUSING BROWN RUST IN MULBERRY
Peridiopsora mori (Barclay) K.V. Prasad, B.R.D. Yadav & Sullia is one of the fungi which cause brown leaf rust on Mulberry (Morus spp.). Leaf rust disease is one of the major diseases affecting Mulberry (Morus sp.). Synt...
COMPARATIVE PHYSICO CHEMICAL ANALYSIS OF VYOSHADIVATI– AN AYURVEDIC POLYHERBAL FORMULATION W.S.R TO MARKET SAMPLES
The quality control assessment of herbal formulations is of great significance to justify their acceptability in the modern system of medicine though the drug may be therapeutically potent. Ayurvedic formulations prepare...
PHARMACOGNOSY AND PHYTOCHEMICAL ANALYSIS OF LEAF GALLS OF MANGIFERA INDICA L
The leaf galls of Mangifera indica L. are very characteristic and possess medicinal properties, due to their phytochemical profile. Hence, a pharmacognostic and phytochemical study was carried out. The microscopic evalua...