Antioxidative Effects of Allium Cepa Essential Oil in Streptozotocin Induced Diabetic Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 4
Abstract
Aim. This study was undertaken to investigate the antioxidative effect of allium cepa essential oil in streptozotocin induced diabetic albino rats through assessment of the lipid peroxidation, serum lipid profile, blood glucose and serum insulin, in addition to histoliogical and histochemical study of liver and kidney. Material and Methods. Diabetes mellitus was induced in 20 out of 30 adult male albino rats, using subcutaneous injection of 60 mg/kg b.w. streptozotocin. Diabetic rats were divided into two groups, one was taken onion essential oil orally (100 mg/kg b.w.) for 21 days (treated group). The other group received no onion oil. The remaining non-diabetic rats (negative control group) received neither streptozotocin nor the onion essential oil. Results. It was found that treatment with onion essential oil, resulted in a significant decrease in serum lipids, lipid peroxide formation, blood glucose and increase in serum insulin. All the histological differences caused by diabetes were converted to normal in the treated group. Conclusion. We suggest here that the mode of action of allium cepa (onion) as antidiabetic may be caused by the antioxidant properties of its essential oil components thereby preventing hyperglycemia and reducing lipid profile together with converting liver and kidney pathology caused by diabetes to normal pattern.
Authors and Affiliations
Neveen Abou El-Soud| National Research Center, Complementary Medicine, Cairo, Egypt, Mona Khalil| National Research Center, Cultivation and Production of Aromatic and Medicinal Plants, Cairo, Egypt
Keywords
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- EP ID EP8767
- DOI 10.3889/MJMS.1857-5773.2010.0118
- Views 309
- Downloads 17
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