Antiulcerogenic activity of Solenostemon monostachyus
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 2
Abstract
Objective: Solenostemon monostachyus P. Beauv (family Lamiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer activity. Materials and Methods: The effects of extract of Solenostemon monostachyus (75 - 225 mg/kg) and fractions (Aqueous and chloroform, 150 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results: The effect of ethanol extract of S. monostachyus (75 – 225 mg/kg) and fractions on experimentally induced ulcer were studied in rats. The extract (75 – 225 mg/kg) inhibited ethanol, indomethacin and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effect of the extract was comparable to that of the standard drugs used with the dichloromethane fraction having the highest activity. Conclusion: Thus, S. monostachyus extract demonstrated a good antiulcer activity which supports the use of this plant in the traditional medicine to treat ulcers.
Authors and Affiliations
Louis U. Amazu, Bassey S. Antia, Jude E. Okokon
Keywords
Related Articles
- EP ID EP49613
- DOI -
- Views 194
- Downloads 0
Pharmacological activity of Fumaria indica - A review
Fumaria indica (Hausskn.) Pugsley (Fumariaceae), known as “Fumitory”, is an annual herb found as a common weed all over the plains of India and Pakistan. Plant is used widely used in Unani and Ayurvedic system of medic...
Isolation of Daphnetin 8-methyl ether from Daphne oleoides and its Anti-bacterial activity
The aim of the present work was to isolate and identify secondary metabolites of Daphne oleoides, which was not phytochemically analysed in this important geographical region of the world until now, followed by the det...
Anti-hyperglycaemic activity of Pergularia daemia (Forssk.) Chiov
Pergularia daemia (Forssk.) Chiov. is commonly known as ‘Velipparuthi’ and its leaves are traditionally used to treat fevers, rheumatism, liver disorders, emetic and expectorant. The present work is aimed to evaluate t...
Lipid-lowering effect of Vernonia amygdalina leaf extracts on Triton WR 1339 – induced hyperlipidaemia in the rats
Vernonia amygdalina is a common plant reported to have several health benefits. This study investigated the dose dependent hypolipidemic potentials of the leaf extracts, following Triton WR 1339 induced hyperlipidemia....
Anti-Helicobacter Pylori and Cytotoxic activity of detoxified root of Plumbago auriculata, Plumbago indica and Plumbago zeylanica
Anti-Helicobacter pylori and cytotoxic activity of detoxified root ethanol extract of Plumbago auriculata, Plumbago indica and Plumbago zeylanica. These three Plumbaginales root were detoxified with lime water and prep...