Apolipoproteins: Risk Assessment Tools For Coronary Heart Disease.
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 2
Abstract
Myocardial Infarction (MI) is one of the major causes of morbidity and mortality in the world. Dyslipidemia is one of the important risk factor. It initiates atherosclerotic plaque formation, finally resulting in degeneration of endothelial cell function which enhances the coagulability of blood by activation of various factors for which apolipoproteins have been implicated. Apolipoprotein A-1 (apo A1) and apolipoprotein B (apo B) are the protein constituents of high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), respectively. Apo A-1 and HDL-C are antiatherogenic whereas Apo B and LDL-C are atherogenic. Objectives: To evaluate and to compare the serum concentrations of apo A1, apo B and lipid profile between Coronary Heart Disease (CHD) patients and healthy subjects and to establish interrelationship if any, between apolipoproteins and lipid profile in CHD patients. Methodology: In this study we have taken a group of 60 clinically proven CHD patients and an equal number of age and sex matched healthy subjects from whom blood was drawn for assay of apo A1, apo B by Immunoturbidimetric method and lipid profile by Enzymatic methods. Appropriate statistical analysis was done. Results: A significant rise in serum apo B, total cholesterol, LDL-C, triglycerides and significant fall in serum apo A1, HDL-C was seen in CHD patients compared to normal subjects (p value < 0.05). Conclusion: The results of the current study establishes apo A1and apo B are useful biomarkers as well as strongly related to CHD in addition to the levels of serum lipids.
Authors and Affiliations
Dr. Leela . P, Dr. Mamatha . B. V, Dr. Chandrakanth . K. H, Dr. Kashinath . R. T
Keywords
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