Are antidepressants useful in bipolar disease?
Journal Title: Archives of Depression and Anxiety - Year 2017, Vol 3, Issue 2
Abstract
The treatment of bipolar depression is the subject of intensive research, as shown by the numerous references obtained only in the last year using the terms “bipolar depression and treatment” in MEDLINE. This is one of the signs of effervescence in the treatment of this affection leading to publication of consensus in North America and the United Kingdom which often don’t deal with clinical realities [1]. These publications systematically evaluate best practices, validate first choices and point out areas where there is not enough literature to produce best clinical practices [2]. The treatment of bipolar depression is certainly an area where a large number of randomized, double-blind studies and a strong evidence-based treatment algorithm produce data to refine our practices. But, although these results are endorsed by respected experts in the field, the detailed study of the references shows that most of these studies are carried out on limited samples, which are not very representative of our clinical population. However, the STAR-D study, funded by the NIMH, gives us very interesting data in the treatment of recurrent depressions [3]. These data are based on a large sample of relevant clinical population and recruited in multicenter sites.
Authors and Affiliations
Bourin Michel
Keywords
Related Articles
- EP ID EP334496
- DOI 10.17352/2455-5460.000025
- Views 38
- Downloads 0
Potential Involvement of Mitochondrial Dysfunction in Major Depressive Disorder: Recent Evidence
Major depressive disorder (MDD) is a leading cause of morbidity and mortality, and it is a common psychological disorder in the world. Present antidepressants modulate monoamine systems directly or indirectly, because MD...
Are antidepressants useful in bipolar disease?
The treatment of bipolar depression is the subject of intensive research, as shown by the numerous references obtained only in the last year using the terms “bipolar depression and treatment” in MEDLINE. This is one of t...
Electrophysiological Profiling of Depression in the Elderly
Frontostriatal system functioning has been proposed to underpin performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-rela...
Postpartum depression: An overview
Bringing a child into the world causes a lot of upheaval and it is normal, after childbirth, to feel sometimes happy, sometimes sad and irritable. Soon after the birth of their child, the majority of women (about 80%) ex...
Different Patterns of Attentional Bias in Subjects with Spider Phobia: A Dot Probe Task using Virtual Reality Environment
Background: Cognitive theories posit that small animal phobics develop a hypervigilance-avoidance attentional pattern when coping with threat. However, empirical research has failed to obtain consistent results. We aimed...