Assessment of brown adipose tissue activity in rats by 99mTc-sestamibi uptake.
Journal Title: Physiological Research - Year 2006, Vol 0, Issue
Abstract
Brown adipose tissue (BAT) physiology and imaging have recently attractedconsiderable attention. BAT is characterized by both enhanced perfusion and increased mitochondrial activity;(99m)Tc-sestamibi is a lipophilic cationic tracer that concentrates in mitochondria. Data on the accumulationof (99m)Tc-sestamibi in BAT are currently lacking. This study investigates the in vivo (99m)Tc-sestamibiuptake in rat BAT. (99m)Tc-Sestamibi was administered in male Wistar rats of various age and body sizeand (99m)Tc-sestamibi uptake was in vitro measured in BAT and white fat (WF) along with cytochrome coxidase (CCO) activity. Both (99m)Tc-Sestamibi uptake and CCO activity were higher in BAT than in WF(P < 0.05). (99m)Tc-Sestamibi uptake in both BAT and WF was negatively related to body weight (r = -0.96and -0.89 respectively) as was the BAT / WF uptake ratio (r = -0.85). These data show a higher (99m)Tc-sestamibiuptake in BAT compared to WF, in agreement with the high mitochondrial content and respiratory activityof the former. The strong negative correlation between (99m)Tc-sestamibi uptake in BAT and body weight(negative allometry), is in accordance to increased needs of thermogenesis in smaller animals. Implicationsof increased (99m)Tc-sestamibi uptake in BAT in radionuclide imaging are also discussed.
Authors and Affiliations
D Kyparos, G Arsos, S Georga, A Petridou, E Papageorgiou, V Mougios, C Matziari
Keywords
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