Cross-Generational Effect of Prenatal Morphine Exposure on NeurobehavioralDevelopment of Rat Pups.
Journal Title: Physiological Research - Year 2005, Vol 54, Issue 6
Abstract
Prenatal exposure to opiates can have devastating effects on the developmentof human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation.The present study was aimed at identifying cross-generational effects of prenatal morphine exposure inSprague-Dawley rats. Pregnant rats were injected subcutaneously with either saline or morphine (10 mg/kg)twice daily during gestational days 11-18. Litter size, percentage of males and females, anogenital distances(AGDs), righting reflex, and body weight were assessed in prenatally morphine-exposed pups (first generation)and their offspring (second generation). Both prenatally morphine-exposed pups and offspring of prenatallymorphine-exposed dams exhibited an increased latency to right. Additionally, second generation pups wereslower in righting than first generation pups. During the early postnatal period the second generationpups weighed less than the first generation regardless of drug exposure. The AGDs of second generationmale pups were decreased relative to the first generation. Our data provide important novel informationabout the trans-generational effects of maternal opiate abuse that may be useful for understanding/ evaluatingthe teratogenic effects of prenatal opiate exposure.
Authors and Affiliations
I Vathy, R Slamberová, M Riley
Keywords
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