Late effects of postnatal administration of monosodium glutamate on insulinaction in adult rats.
Journal Title: Physiological Research - Year 2001, Vol 49, Issue
Abstract
Early postnatal administration of monosodium glutamate (MSG) to rats inducesobesity, hyperinsulinemia and hyperglycemia in adulthood, thus suggesting the presence of insulin resistance.We therefore investigated the effects of insulin on glucose transport and lipogenesis in adipocytes aswell as insulin binding to specific receptors in the liver, skeletal muscle and fat tissues. An increaseof plasma insulin, glucose and leptin levels was found in 3-month-old rats treated with MSG during thepostnatal period. The attenuation of insulin stimulatory effect on glucose transport was observed inMSG-treated rats. Despite the lower basal and insulin-stimulated glucose uptake, the incorporation ofglucose into lipids was significantly higher in MSG-treated rats, suggesting a shift in glucose metabolismtowards lipid synthesis in fat tissue. Insulin binding to plasma membranes from the liver, skeletal muscleand adipocytes was decreased in MSG-treated rats. This is in agreement with the lower insulin effecton glucose transport in these animals. Furthermore, a decreased amount of GLUT4 protein was found inadipocytes from MSG-treated obese rats. The results demonstrated an attenuation of insulin effect onglucose transport due to a lower insulin binding and lower content of GLUT4 protein in MSG-treated rats.However, the effect of insulin on lipogenesis was not changed. Our results indicated that early postnataladministration of MSG exerts an important effect on glucose metabolism and insulin action in adipocytesof adult animals.
Authors and Affiliations
S Zórad, M Ficková, L Macho
Keywords
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Late effects of postnatal administration of monosodium glutamate on insulinaction in adult rats.
Early postnatal administration of monosodium glutamate (MSG) to rats inducesobesity, hyperinsulinemia and hyperglycemia in adulthood, thus suggesting the presence of insulin resistance.We therefore investigated the effec...