Second derivative of the finger arterial pressure waveform: an insight intodynamics of the peripheral arterial pressure pulse.
Journal Title: Physiological Research - Year 2005, Vol 54, Issue 6
Abstract
The study investigated second derivative of the finger arterial pressurewaveform (SDFAP) in 120 healthy middle-aged subjects and in 24 subjects with essential hypertension.SDFAP consists of 5 sequential waves 'a'-'e'. Their normalised magnitudes (B/A, C/A, D/A, and E/A) werecalculated. In multivariate regression analysis, B/A and C/A correlated only with age. D/A independentlycorrelated with age, heart period, mean blood pressure (MBP), body height, and gender. E/A independentlycorrelated with age and MBP. D/A and E/A were higher (0.42 +/-0.16 vs 0.33+/-0.14, p = 0.05 and 0.63+/-0.15 vs 0.45+/-0.14, p < 0.001), whilst B/A and C/A were lower (1.04 +/-0.16 vs 1.20+/-0.17, p = 0.002and 0.09+/- 0.15 vs 0.26 +/- 0.20, p = 0.001) in hypertensives compared to sex- and age-matched controls.After adjustment for MBP, heart period, and body mass index (ANCOVA), independent discriminative powerwas preserved only for indices B/A and C/A (p = 0.001 and 0.021, respectively). Therefore, B/A and C/Aprovide additional information to simple clinical characteristics and might reflect the structural alterationof arterial wall in hypertensive subjects.
Authors and Affiliations
D Wichterle, J Simek, V Melenovský, S Svacina
Keywords
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