Assessment of Efficacy of Clonidine with Midazolam as Premedication Agent: A Comparative Study
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Background: The present study was conducted to compare the efficacy of midazolam with clonidine as a premedication in children. Materials & Methods: This study was conducted in department of anaesthesia, Rajshree Medical Research Institute & Hospital, Bareilly, Uttar Pradesh (India) on 50 children with ASA grade I and II were selected. They were divided into 2 groups of 25 children each. Group I received 4mcg/kg of oral clonidine while group II received 0.5mg/kg as a premedication about I hour before induction of anaesthesia. We compared drug acceptance and sedation level in both groups. Results: In group I, score 1 was seen in 11, 2 in 7 and 3 in 8 children. In group II, score 1 was seen in 14, 2 in 6 and 3 in 5 children. Score 1 was seen in 12, score 2 in 10 and score 3 in 3 children at 15th minutes. At 30th minute, score 1 was seen in 14, score 2 in 9 and score 3 in 2 children. At 6oth minute, score 1 was seen in 15 children, score 2 in 10 children. Score 1 was seen in 22, score 2 in 3 at 15th minutes. At 30th minute, score 1 was seen in 20, score 2 in 2 and score 3 in 3 children. At 60th minute, score 1 was seen in 18 children, score 2 in 3 and score 3 in 4 children. The difference was significant (P-0.01). Conclusion: Clonidine found to be better pre anesthetic agent as compared to midazolam. Better sedation, and drug acceptance score makes it as an alternative to midazolam.
Authors and Affiliations
Randhir Singh, Rangit Priyakar Pandey
Keywords
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- EP ID EP536672
- DOI 10.21276/ijmrp.2018.4.5.009
- Views 80
- Downloads 0
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