Assessment of Renal Impairement and Dyslipidemia in Subclinical Hypothyroidism
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 1
Abstract
Subclinical hypothyroidism also referred to as mild thyroid failure and is diagnosed when peripheral thyroid hormone levels are within the normal range, but thyroid stimulating hormone (TSH) is mildly elevated. It is common, occurring in 3-8% of the population increasing with age and being more common in women. Mild thyroid failure represents an early stage of thyroid disease that will commonly progress to overt hypothyroidism. Progression has, in fact, been reported to occur in approximately 3–18% of affected patients per year. To maintain the growth and metabolism of renal system, they play an indispensable role. Decrease or fall in the activity of renal system is accompanied by compensatory alteration in the level, synthesis and metabolism of thyroid hormones. It is well established fact that renal system is affected by hypothyroid states of the body. Hence; we evaluated the effect of hypothyroidism on the renal functions of the body. Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. The serum creatinine concentration increases in hypothyroid patients due to reduction of glomerular filtration rate because of hemodynamic changes in severe hypothyroidism.Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated to explore hypothyroidism. In general, overt and subclinical hypothyroidism is associated with hypercholesterolemia mainly due to elevation of low density lipoprotein (LDL) cholesterol levels, whereas high density lipoprotein (HDL) cholesterol concentration is usually normal. Therefore; hypothyroidism constitutes a significant cause of secondary dyslipidemia. Thyroid dysfunction causes significant changes in kidney function. Goal of treatment is to replace sufficient amount of thyroid hormone so as to reduce the TSH to within the normal range to prevent the renal complications of hyperuricemia and hypercreatinemia.
Authors and Affiliations
Dr. P. Jayakala
Keywords
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