Assessment of selected oxygen metabolism in patients with chronic hepatitis C during treatment with pegylated interferon alfa and ribavirin
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 11
Abstract
Introduction. In the year 2012 there were several hundred millions patients with chronic hepatitis C (CHC). The etiopathogenesis of this disease is not clear. It was suspected that free radicals may play an important role in the process.Aim. The aim of the research was to analyse of the indictors of oxygen metabolism among the patients with CHC treated with pegylated interferon alpha (Peg-IFN) and ribavirine (RBV).Material and methods. The study was carried out on a group of 31 patients (23 males and 8 females) with an average age of 41 +/- 11. During the therapy results were controlled four times (before treatment, in the 12th, 24th and 48th week), measuring the level of superoxide anion radicals at rest and after stimulation, the malonic dialdehyde concetration (MDA), the activity of catalase (Cat), glutathione preoxidase (Gpx) and superoxide dismutase.Results. The results showed an elevated concentration of superoxide anion radicals for patients with chronic hepatitis C. The concentration decreased after the treatment. The MDA concentration was lower after the Peg-IFN + RBV treatment. The activity of antioxidant barrier was a proof of elevated rates of indicator enzymes in the case of patients with CHC and of continuous activity reduction during the treatment with Peg-INF and RBV.Conclusions. 1. CHC should be described as an oxidative stress disease. 2. Oxidative stress CHC stimulate the antioxidant barrier to generate antioxidative enzymes. 3. Treatment with Peg-IFN and RBV has a positive impact on the oxygen metabolism among patients with CHC, reducing the production of free oxygen radicals and the activity of the antioxidative barrier.
Authors and Affiliations
Jarosław Kałuża, Paweł Fijałkowski, Daniela Dworniak, Jan Błaszczyk, Anna Skubała
Keywords
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