Assessment of Serum Galectin-8 in Iraqi Patients with Rheumatoid arthritis
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Background:Rheumatoid arthritis (RA) is chronic inflammatory arthritis disease with significant morbidity and mortality .Early diagnosis is important for better treatment and outcome.Galectins are potent immune regulators and modulate a range of pathological processes, such as inflammation, autoimmunity, and cancer, Accumulated evidence shows that several family members of galectins play positive or negative roles in the disease development of RA, through their effects on T and B lymphocytes, myeloid lineage cells, and fibroblast-like synoviocytes. (1). Objective: to assessserumGalectin-8 in Iraqi Patients with RA and its validity in diagnosis of RA Patients and Methods: This case control study included 90 subjects.Fiftyof them were patient diagnosed as established RA according to the 2010 American College of Rheumatology/European League Against Rheumatism (2010 ACR/EULAR) classification criteria for Rheumatoid arthritis and compared with 40 apparently healthy control group.serum Galectin-8 was measured for patients and controls Results:Mean serum level of Galectin-8 was statistically significantly lower in patients group (36.68±25.79) than controls group (182.93±87.83), (P-value < 0.001).At the optimum cut off value of serum gal-8 ≤ 95.7 we found that maximum accuracy was 95.6 , sensitivity98.0%, specificity 92.5% and AUC was 0.971 . Conclusion: serum galectin-8 was significantly lessin RA patients compared to controls, also the biomarker has excellent valid results to differentiate between patients and controls
Authors and Affiliations
Tarek. Q. Muss, M. AL- Faham, Faiq I. Gorial
Keywords
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- EP ID EP395673
- DOI 10.9790/3008-1304066871
- Views 44
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