Test of Effectiveness of Thorny Palm Skin (Salacca Edulis) and Noni Extract (Morinda Citrifolia L) On Decreasing the Blood Sugar Rate Of Male Mice (Mus Musculus)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
This research is meant to know the effectiveness of thorny palm skin (Salacca edualis) and noni (Morinda citrifolia L) extract on the decrease of mice’ blood sugar level (Mus musculus L.). The experimental animals used were male DDY strains of 2-3 months old with 27 samples. The mice were saturated with sugar solution (Sukrosa) so as hyperglycemia occurred, then the mice were divided into 9 treatment groups and 3x replicates namely; control treatment, thorny palm skin and noni extract treatment (F1) and treatment of 150, 200, 250 mg / KgBB (F2) dose. Administration of sugar solution was given for 1 week. Giving sugar solution done orally, mice were given feed in the form of pellets and drinking water 2x a day. Blood sugar taken before and after administration of the extract using a glucometer (NESCO-Multiple Check). The data obtained were then analyzed using varian analysis (Anava) and LSD test using SPSS 23. The result of the two-lane anava analysis showed that the significance level of 0,000 <0.05 which means the hypothesis test decision stated H0 rejected means that there is the effect of giving thorny palm skin extract (Salacca edualis ) and the extract of Morinda citrifolia L. to decrease blood sugar level. Thorny palm skin extract has a faster effect in lowering blood sugar levels of mice with a dose of 250 mg / kgBB treatment compared with noni fruit extract, as it contains pterostilbene compounds, pterostilbene is an antidiabetic substance that plays a direct role in decreasing blood sugar levels.
Authors and Affiliations
*Ani Sulistyarsi1 ,, Sri Utami, Yuliantika Herdiana Putri3
Keywords
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