Association Between Schiffs and Mannich Bases of 5-Substituted-1h Indole-2, 3 Diones and Evaluation of Antiepileptic Activity: Findings from PTZ Model Casual Pathway‐Based Multi‐Site Recruitment
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 3, Issue 3
Abstract
We report here novel Schiff bases of 5-substituted-1H Indole-2, 3 Dione comparing modified with aromatic primary amine and hydrazine. A recombinant with Mannich base has been synthesized. A structure of the synthesized compounds was analyzed for structure confirmed by mass spectral data. Compound 1a-p has screened for anti-convulsant activity, increased in latency time and reduction in duration of convulsion and standard drug when compared, sodium valporate 300mg/kg. PTZ dose of 90mg/kg produced severe clonic convulsions in 88% of the mice injected, with a mean onset time of 3.61 ± 0.5 min and 80% mortality. Clonic convulsive activity lasted 2.3±0.45 min and has postictal period of decreased motor activity and subsequently. Test result revealed that compounds at dose of 300 mg/kg, the severity and duration of the convulsive episode following PTZ has not observed. Epilepsy has accepted group of disorders in which there are recurrent episodes of altered cerebral function associated with paroxysmal excessive & hypersynchronus discharge of cerebral neurons [1]. The clinical accompaniments of those episodes seizures vary in manifestation from brief lapses of awareness to prolonged bouts of unconsciousness incontinence. It has episode of neurological dysfunction a seizure. Isatin (1H-indole-2, 3-dione) and scaffold demonstrated a diverse array of biological activities. It has 5-halo derivatives have reacted to form the Schiff’s base, Mannich bases to form C-N, C=N bonds, from the spectral studies, Isatin undergo reaction at C-3 and N-1 position and showed the anti-convulsant activity. In round bottom flask took 9g (0.05 moles) of chloral hydrate in 86 mL of water added mixture 7g of sodium sulfate and solution of 3.1g (0.03moles) of aniline (4-halo substituted derivatives) in 30mL of water containing 4-5 mL of HCl added (dissolved amines). Finally, the solution of hydroxylamine in 50 mL of water added in the flask. Heat the mixture at 45 0C to dissolved precipitate and then boiled the solution vigorously for 1-2 min. Cooled the solution to room temperature. The precipitate obtained has filtered off. The yield has 80% (Scheme 1).
Authors and Affiliations
Rahul Hajare
Keywords
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- EP ID EP603571
- DOI 10.32474/AOICS.2018.03.000165
- Views 45
- Downloads 0
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