Association between Vascular Endothelial Growth Factor (VEGF) +405 C/G Polymorphism and Hypertension in North West of Iran
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2014, Vol 8, Issue 1
Abstract
Blood pressure is one of the main factors in global mortality. People with systolic blood pressure above 140 mmHg and diastolic blood pressure above 90 mmHg are known as patients with hypertension. Complications of the hypertensionare numerousincluding visual impairment as important complication and kidney, brain, and heartdamages. If hypertension is not treated, is oftenfatal. Genetic plays a pivotal role in blood pressure regulation;Where as Hypertensionis amultifactorialand familial condition..However, little is known regarding the contribution of polymorphisms inVEGF gene to essential hypertension (EH). We aimed to investigate the association between +405 VEGFC/G single nucleotide polymorphism (SNP) and occurrenceof EH in a population of 100 subjectsincluding 50 normal and 50 patients with Eh.In this studywere evaluated triglycerid, blood sugar, cholesterol and body mass index of patients. Genotyping of +405 VEGF C/G (rs2010963) SNP was detected using polymerase chain reaction–restriction fragment length polymorphism(RFLP). Genotype frequencies of GG, GC and CC were respectively 44%, 44% and 12% in hypertensive patients and 16%, 34% and 50% in the control group.Allele frequency of G and C were respectively, 66% and 34% of hypertensive patients and 33% and 67% in the control group. In this study, was found Significant difference between the frequencies and this result was that the +405 VEGF C/G polymorphism is associated with blood pressure.
Authors and Affiliations
Akram Farzi *| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran, email: leili.farzi@yahoo.com, Majid Farshdousti Hagh| Hematology & Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords
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