Association of high sensitivity C – reactive protein (hs-CRP) with unstable angina: An alarm for vulnerable plaques in CAD patients
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction Inflammation plays a crucial role in the development and progression of Coronary Artery Disease HsCRP has been identified as one of the promising inflammatory marker associated with CAD It is synthesized at various sites but its secretion by macrophages residing in vulnerable plaque has been shown to be associated with plaque rupture Unstable angina is linked with vulnerable plaquesAim The study aimed to evaluate the circulatory levels of hsCRP in CAD patients and its association with severity of the diseaseMaterials and Methods In the present study 103 CAD patients diagnosed for coronary artery disease by Coronary Angiography and by ECG findings were included with 96 controls Further CAD patients were sub classified according to number of vessels involved SVD DVD and TVD and type of angina Stable and UnstableResults In the present study anthropometric parameters and lipid profile did not show any significant statistical variation in CAD and control groups except HDL Low levels of HDL have been reported in CAD patients as compared to controls 39561444 446941244 High hsCRP levels have been observed in CAD patients than controls group 507325 19 145 In CAD group CAD patients with unstable angina reported the highest concentration of hsCRP than CAD patients with stable angina independent of number of diseased vessels 786 2361 343 250Conclusion The present study observed highest levels of hsCRP in CAD patients with unstable angina and considered them as the most risky group amongst the CAD patientsKeywords Inflammation Atherosclerosis hsCRP CAD Unstable angina
Authors and Affiliations
Deepali Vidhate, James Thomas, Becky Thomas, Simran Dhadiala, Arpit Murarka
Keywords
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- EP ID EP475203
- DOI 10.18231/2394-6377.2018.0097
- Views 46
- Downloads 0
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