Association of Serum Parathyroid Hormone with Severity of Coronary Artery Disease
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Elevated serum parathyroid hormone (PTH) levels are associated with increased risk of systemic hypertension, left ventricular hypertrophy, diastolic dysfunction, reduced cardiac contractility, atherosclerosis, vascular calcification, ischemic heart disease and peripheral vascular diseases especially in chronic kidney disease and haemodialysis patients. This prospective study aims to evaluate the association between serum parathyroid hormone concentration and coronary angiogram in patients of stable coronary artery disease. Serum PTH level was measured in angiographically confirmed chronic stable angina patients. Patients were divided into groups according to serum parathyroid level as follows: group 1, Serum level ≤ 29 pg/ml; group 2, 30 to 70 pg/ml & group 3, ≥ 71 pg/ml. Coronary angiographic profile including number(s) of coronary artery, pattern of segmental coronary artery involvement and syntax score for complexity of lesions were correlated with the serum parathyroid hormone concentration. One hundred and forty (140) patients were evaluated. Mean serum PTH level were 24.10 pg/ml, 50.44 pg/ml and 85.5 pg/ml in groups 1, 2 and 3 respectively. Higher serum PTH levels were directly correlated with number of coronary artery involvement, syntax score and not with the pattern of segmental coronary artery (LAD / LCx / RCA). Keywords: serum parathyroid hormone, stable coronary artery disease, syntax score.
Authors and Affiliations
Dr. Pravin Kumar Jha, Dr. Prabin Kumar Shrivastava, Dr. Umashanker Prasad Keshri
Keywords
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