Association of subclinical hypothyroidism with atherosclerosis in central India
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 12
Abstract
Introduction: Overt hypothyroidism is widely recognized as a risk factor for atherosclerosis and cardiovascular disease, but recently subclinical hypothyroidism has also shown as an independent risk for it. Subclinical hypothyroidism also has close association with dyslipidemia and lowgrade inflammation leading to atherosclerosis which can be assessed by carotid intimal medial thickness. Objective: The objective of the study was to explore the correlation of subclinical hypothyroidism with atherosclerosis in the form of dyslipidemia, C Reactive Protein and Carotid Intimal Medial Thickness in patients of central India. Methods: This study was conducted at department of medicine in GMC, Bhopal. It was a case control study among which 100 patientswith raised TSH and normal T3/T4 values were included as cases in the study and 50 controls with normal TSH/T3/T4 were taken.Three groups were made according to TSH values as euthyroids (<5.5), Subclinical Hypothyroids group 1(5.5-10) &group2(>10) and their fasting lipid profile, CReactive Protein levels and Carotid Intimal Medial Thickness were measured. Results: We compared the Subclinical Hypothyroids with euthyroids subjects in which lipid profile was highly significant (<0.01)and showed positive correlation in both groups of Subclinical Hypothyroids except for high density lipoprotein.In cases where TSH(>5.5) the CRP was found to be significantly associated showing presence of low grade inflammation in these patients. The study also showed that mean Carotid Intimal Medial Thickness was higher in Subclinical group as compared to euthyroids but only when TSH(>10). Conclusion: This study concludes that subclinical hypothyroidism is characterized by dyslipidemia with increased Carotid medial intimal thickness value and positive CReactive Protein suggesting the future development of cardiovascular disease in these patients.
Authors and Affiliations
Vibhor Upadhyay, K. Deopujari, T. N. Dubey, A Sharma
Keywords
Related Articles
- EP ID EP277629
- DOI 10.17511/ijmrr. 2017.i12.04
- Views 152
- Downloads 0
Incidence of Helicobacter Pylori in upper gastrointestinal lesion
Introduction: Helicobacter pylori are gram-negative bacillus. It is noninvasive and live in gastric mucus, with the small proportion of bacteria adherent to the mucosa. Its spiral shape and flagella render Helicobacter p...
A comparative study to determine vitamin D status in type 2 diabetes and normal subjects in south India
Background: Vitamin D deficiency is common in general population in India in spite of adequate sunlight. We have decided to compare the prevalence of vitamin D deficiency in type 2 diabetes and normal individuals. Method...
Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India
Introduction: Platelets from patients with type 1 and type 2 diabetes exhibit enhanced platelet aggregation activity early in the disease course that may precede the development of cardiovascular diseases. Both atheroscl...
Role of yoga in study of pulmonary function test in young healthy adults
Introduction: Yoga has been reported to improve pulmonary function tests in healthy and respiratory illness. Aim: This study was done to find out the effects of yoga practice on pulmonary function tests. Materials and me...
Musculoskeletal manifestations in diabetic patients at a tertiary center
Introduction: Diabetes mellitus (DM) is a major public health problem worldwide. India is popularly known as a “diabetes capital of the world”. Musculoskeletal (MSK) disorders are common in diabetic patients. Objective :...