Association of systemic inflammation and oxidative stress in adolescent diabetes mellitus patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Oxidative stress has been implicated in the pathophysiology of a number of diseases such as arthritis, hypertension and inflammatory diseases. Although previous evidences provided extensive literature about the biological role of antioxidant enzymes in diabetes mellitus (DM), there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes along with marker of systemic inflammation in adolescent DM patients. Therefore, the objective of present study was to estimate the level of C-reactive protein (CRP), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSHPx) and Ceruloplasmin in adolescent DM patients. 20 patients of either sex (10-19 years age group) suffering from DM and 20 normal healthy individuals served as control; were included in the study. Above mentioned parameters were estimated using standard methods and data from patients and controls were compared by using Student’s t-test. Erythrocyte SOD, CAT and GSHPx activity were significantly low in DM subjects (P<0.001) whereas plasma ceruloplasmin level was found to be significantly high (P<0.001) as compared to healthy controls. These findings suggest that combined effect of inflammation and free radical generation is involved in the pathogenesis of DM, characterized by imbalance in antioxidant enzyme status and enhanced CRP levels, which served as an excellent marker of oxidative stress and systemic inflammation in adolescent diabetes mellitus patients. Keywords:Antioxidant enzymes, Catalase, Ceruloplasmin, C-reactive protein, superoxide dismutase
Authors and Affiliations
Manoj Kumar Nandkeoliar, Rahul Saxena, Alok Milton Lal
Keywords
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