Asymmetric Arylation Reaction of Pyrazolones
Journal Title: 河南科技大学学报（自然科学版） - Year 2018, Vol 39, Issue 1
Abstract
The enantioselective arylation reaction of pyrazolones with quinone monoimines promoted by a chiral phosphoric acid was disclosed.The effects of catalyst, reaction solvent, and temperature on asymmetric arylation reaction were analyzed.The results show that various 4-aryl-4, 4-disubstituted pyrazolones are synthesized with95% productivity and 96% enantiomeric excess at room temperature by using 1, 4-dioxane as the reaction solvent and chiral 9-anthracenyl spirocyclic phosphonic acid as catalyst.
Authors and Affiliations
Fangzhi HU, Hui CHEN, Shuowen YU, Xiaomei ZHANG
Keywords
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