Atherosclerosis Biomarkers Among Egyptian Patients with Systemic Lupus Erythematosus: Population Based Study
Journal Title: Immunological Disorders and Immunotherapy - Year 2018, Vol 3, Issue 1
Abstract
Systemic lupus erythematosus is associated with increased risk of atherosclerosis; endothelial dysfunction is believed one of the most important initial steps of the atherosclerosis process. The aim of this study is to evaluate endothelial microparticles (EMPs) (VCAM-1/CD105) in addition to Carotid intima-media thickness (cIMT), as biomarkers of atherosclerosis, among Egyptian Systemic lupus erythematosus (SLE) patients and its correlation to SLE related risk factors. We compared data obtained from 60 Egyptian SLE patients neither of them had diabetes, hypertension nor smokers, with 30, age and sex matched healthy volunteers. Both patients and controls were subjected to full history taking and clinical examination as well as basic laboratory investigations in addition to VCAM-1 ELISA, CD105 by flow cytometer and Carotid arteries ultrasound to assess intima-media thickness and the presence of plaques. Our results revealed highly significant increase of cIMT, CD105, VCAM-1, total cholesterol and LDL-cholesterol in SLE patients compared to normal controls (P <0.001). In comparing SLE patients with increased cIMT with those with normal cIMT, we found significant increase in LDL cholesterol, steroid duration and highly significant increase of steroid cumulative dose and disease duration. Also, SLE patients with positive anti-dsDNA showed significant increase in cIMT (P<0.05) in comparison to anti-dsDNA negative patients at the time of sampling. Our results also demonstrated no correlation between Anti-Cardiolipin antibodies (ACL) and cIMT, VCAM-1 or CD105. We found that SLE patients had a significant increase in cIMT, VCAM-1 and CD105 compared with the controls. This significant increase in these atherosclerotic biomarkers was not correlated with indices of disease activity or presence of anti-dsDNA or ACL antibodies but correlated with disease and steroid duration, steroid cumulative dose, age and LDL-C level.
Authors and Affiliations
El-Desouki Fouda, Mahmoud Eid, Mona Hilmy Al-Rayes, Mokhtar Ragab and Gamal Abdelghany Khalifa
Keywords
Related Articles
- EP ID EP743460
- DOI -
- Views 22
- Downloads 0
Profile of Cytotoxic Tcd8 Cells in Different forms of Malaria in Children
Introduction: Our study focused on the value of TCD8 cytotoxicity in susceptibility to severe malaria in endemic areas. The global purpose of the work hereby was to evaluate adaptive cellular immunity during Plasmodium f...
Th1 Cytokine Profile Associated of Severe Malaria Resistance In Endemic Areas
Introduction: Malaria, a disease caused by protozoan parasites of the genus Plasmodium. Despite the premunition, some adults still experience the severe form of malaria. The study hereby aims to investigate the involveme...
MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines
The MHC class I related chain A and B have been of much interest in the recent past. MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells a...
P-Selectin is a Key Molecule Underlying the Pathophysiology of AspirinExacerbated Respiratory Disease
Recently, the evidence for platelet association with allergic diseases has been established by many researches. Activated platelets contribute to airway hyper reactivity, bronchoconstriction, airway inflammation and airw...
A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance
In this report, investigations were done to study human GULP/ CED 6 genes role in presenting cancer cells to scavenger cells. CED 6 SiRNA was used to knock out the gene in Astrocytoma (HTB-12) cell lines to study its eff...