Bacterial Agents and their Antibiotic Resistance Pattern in Neonatal Blood Cultures - A Hospital Based Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Bacterial infections are an important cause of neonatal mortality and morbidity worldwide. Despite advances in neonatal care, antibiotic resistance among common pathogens and the emergence of multidrug-resistant organism continues to be a challenge in the neonatal intensive care units (NICU) today. Methods: This retrospective hospital based study was conducted over a period of 2 years. We analyzed the results of neonatal blood cultures, their bacteriological profile and the antibiotic resistance pattern. Results: Out of 1084 neonates screened for sepsis there were 241 (22.23%) positive blood cultures. After excluding coagulase-negative Staphylococcus and Flavobacterium which were suspected to be skin contaminants and also fungi, we analyzed 52 cases of bacterial growth. The predominant growth was Gram-positive organisms (51.92%), of which Staphylococcus aureus and Enterococcus were the predominant isolates. The Gram-negative organism constituted 48.08%, of which Acinetobacter (19.23%) was the most common followed by coliforms (13.46%). The Gram-positive organisms had high resistance to penicillin and ampicillin but were highly sensitive to vancomycin, linezolid, and netilmicin. The Gram-negative group showed high resistance to ampicillin and quinolones and high susceptibility to netilmicin, amikacin, and meropenem. Conclusion: Periodic surveillance of the bacterial agents and understanding their antibiotic resistance pattern will definitely help in formulating rational antibiotic practices in the NICU.
Authors and Affiliations
Peter P Vazhayil, Sindhu Thomas Stephen, P C Nayana Prabha
Keywords
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